An Mg-MOFs based multifunctional medicine for the treatment of osteoporotic pain

作者：Ge, Yongmei; Wang, Kui; Li, Huili; Tian, Ye; Wu, Yutong; Lin, Zhaowei; Lin, Yangyang; Wang, Yansong; Zhang, Jiarong; Tang, Bin^*

来源：MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2021, 129: 112386.

DOI：10.1016/j.msec.2021.112386

• Pain
• Osteoporosis
• Bone formation
• Inflammation
• Ketoprofen
• Mg-MOF-74

Bone pain is the primary problem for patients with osteoporosis. Ketoprofen is clinically used to treat osteoporotic pain, while long-term oral administration of ketoprofen can cause some side effects. In addition, osteoporosis is also accompanied by bone mass loss and inflammation. In this study, we designed a multifunctional drug (Ket@Mg-MOF-74) adopted Mg-MOF-74 to load ketoprofen to treat osteoporotic pain, bone loss and inflammation comprehensively. Mg-MOF-74 was prepared, and the physicochemical characterization proved that it had excellent physical and chemical stability. Ket@Mg-MOF-74 was synthesized by post-synthetic modification method and a high loading rate of ketoprofen was confirmed. Drug release and ion release experiments indicated Ket@Mg-MOF-74 had a good controlled release of ketoprofen and Mg in solution. Cell experiments in vitro proved the compound drug could significantly reduce the expression of pain-related genes of cyclooxygenase 2 (COX2), obviously up-regulated the expression of osteogenic cytokines and remarkably downregulated the secretion of pro-inflammatory factors. Therefore, Ket@Mg-MOF-74 is believed a promising painkiller for osteoporotic bone pain, with the function of anti-inflammatory and promoting bone formation.

• 单位
  6; 南方医科大学; 中山大学