A Coordinative Dendrimer Achieves Excellent Efficiency in Cytosolic Protein and Peptide Delivery

摘要

A coordinative dendrimer delivers 30 types of cargo proteins and peptides into the cytosol of living cells, while maintaining their bioactivity after intracellular release. In their Research Article (DOI: 10.1002/anie.201914970), Y. Cheng et al. report that dendrimers modified with a dipicolylamine/zinc (II) complex are capable of binding proteins through a combination of ionic and coordination interactions. This provides a new strategy to develop robust and efficient polymers for cytosolic protein delivery.

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