科研之友
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摘要
As a critical component for photodynamic therapy toward cancer treatment, photosensitizers require high photoinduced reactive oxygen species generation efficiency, good biocompatibility, and high phototoxicity. Herein, a series of donor-acceptor conjugated polymers containing dibenzothiophene-S,S-dioxide derivatives are designed and synthesized, which can be used as effective photosensitizers. The resulting copolymer PTAS shows strong green light emission with high photoluminescence quantum yields owing to the intercrossed excited state of local existed and charge transfer states. The PTAS nanoparticles can be fabricated by encapsulation with a biocompatible polymer matrix. Upon excitation at 800 nm, these nanoparticles present a relatively large two-photon absorption cross section of 3.29 x 10(6) GM. These nanoparticles also exhibit good photostability in water and thus can be utilized for bioimaging. The tissue-penetrating depths of up to 170 mu m for hepatic vessels and 380 mu m for blood vessels of mouse ear were achieved using PTAS nanoparticles. Furthermore, PTAS nanoparticles show impressive reactive oxygen species generation capability under the irradiation of a white light source. This can be attributed to the effective intersystem crossing between high-level excited state. Upon irradiation with white light (400-700 nm) at 50 mW cm(-2) for 5 min every other day, the tumor growth can be effectively suppressed in the presence of PTAS nanoparticles. These findings demonstrate that PTAS nanoparticles can be used as a photosensitizer for photodynamic therapy.
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单位中山大学; 南方医科大学
