Preparation of Dye Molecule-Intercalated MoO3 Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging-Guided Catalytic Therapy

Authors：Hu, Tingting; Liu, Qian; Zhou, Zhan; Zhao, Wei; Huang, Haoxin; Meng, Fanqi; Liu, Wanqiang^*; Zhang, Qinghua; Gu, Lin; Liang, Ruizheng^*; Tan, Chaoliang^*

Source：Small, 2022, 18(25): 2200595.

DOI：10.1002/smll.202200595

• catalytic therapy
• fluorescence imaging
• layered MoO
• (3)
• organic intercalation
• organic
• inorganic superlattices

Intercalation of organic molecules into the van der Waals gaps of layered materials allows for the preparation of organic/inorganic superlattices for varying promising applications. Herein, the preparation of a series of dye molecule/MoO3 organic/inorganic superlattice nanoparticles by aqueous intercalation of several dye molecules into layered MoO3 for fluorescence imaging-guided catalytic therapy is reported. The long MoO3 nanobelts are treated by ball milling and subsequent aqueous intercalation followed by a cation ion exchange to obtain the dye molecule-intercalated MoO3 organic/inorganic superlattices. Importantly, because of the activation induced by organic intercalation, the Nile blue (NB)-intercalated MoO3-x (NB-MoO3-x) nanoparticles show excellent catalytic activity for the generation of reactive oxygen species, that is, hydroxyl radical (center dot OH) and superoxide anion (center dot O-2(-)), through catalyzing H2O2 and O-2, respectively. Moreover, the intense fluorescence of the intercalated NB molecules endows NB-MoO3-x with the in vivo fluorescence imaging capability. Thus, the polyvinylpyrrolidone-modified NB-MoO3-x nanoparticles can be used for tumor-specific catalytic therapy to realize efficient cancer cell elimination in vitro and fluorescence imaging-guided tumor ablation in vivo.

• Institution
  中国科学院研究生院; 湖南科技大学; 北京化工大学