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摘要
The focus of this research was to investigate the impact of combining curcumin-loaded gold nanoparticles (Au NPs) with P. indica root extracts on kidney stones formed in male Wistar rats. Besides, kidney stones were induced in male Wistar rats through the oral supplementation of 2% ethylene glycol mixed with drinking water. To evaluate the impact of P. indica-curcumin-Au NPs on kidney stones, the rats were given a dose of 150 mg/kg P. indica root extract, 100 mg/kg curcumin, and 100 ppm of gold nanoparticles via administration. Following the treatment, the Wistar rat's kidney tissues were collected and analysed for further research. Curcumin is a primary active ingredient in turmeric that has shown significant biological, pharmacological and diverse effects, such as anti-inflammatory, antifibrotic, and antioxidant properties. Additionally, P. indica root extract has been shown to reduce the formation of oxalate stones in the kidneys. The presence of various phenolic compounds in P. indica such as flavonoids, quinic acids, thiophenes, terpenes, and sterols, are more likely to generate Au NPs. Subsequent addition of curcumin with P. indica root extract accelerates the formation of a complex with Au NPs which was confirmed by X-ray diffraction, UV- visible spectroscopy, Dynamic light scattering and Transmission electron microscopy results. The use of P. indica-curcumin-Au NPs relieved the oxidative stress response in the rat model by decreasing MDA content and raising GSH, CAT, GR, GPx, and SOD levels. Moreover, the combination efficiently inhibited the expression of IL-6, -SMA, collagen I, and MCP1 and protected kidney tissues from deterioration. @@@ [GRAPHICS]
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单位哈尔滨医科大学
