Is there a relationship between neural EGFL like 1 (NELL1) promoter hypermethylation and prognosis of gastric cancer?

作者：Gao, Changlu; Liu, Haibin; Zhao, Yubo; Miao, Xinyu; Zheng, Hongqun^*

来源：Medical Hypotheses, 2022, 158: 110723.

DOI：10.1016/j.mehy.2021.110723

• Hypermethylation
• Gastric cancer
• Promoter
• Prognosis
• Biomarker

We hypothesized that neural EGFL like 1 (NELL1) promoter hypermethylation might be associated with the prognosis of gastric cancer. Some studies considered NELL1 as a tumor suppressor gene and our research confirmed for the first time the hypermethylation in the promoter region of NELL1 by the application of mass spectrometry. Promoter hypermethylation can cause the silencing of tumor suppressor genes and promote tumor progression. Based on present studies and research results, we proposed that NELL1 promoter hypermethylation might be associated with cancer staging and the survival of gastric cancer patients and had prognostic value. We hoped that NELL1 promoter hypermethylation would be applied not only for early detection but also prognosis prediction of gastric cancer and would become a new prognostic biomarker.

• 单位
  哈尔滨医科大学