Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise Therapy of Parkinson's Disease

作者：Liu, Yao; Luo, Jingshan; Liu, Yujing; Liu, Wen; Yu, Guangtao; Huang, Yuting; Yang, Yu^*; Chen, Xiaojia^*; Chen, Tongkai^*

来源：ACS Central Science, 2022, 8(9): 1336-1349.

DOI：10.1021/acscentsci.2c00741

• ALPHA-SYNUCLEIN
• CURCUMIN
• NANOPARTICLES
• DELIVERY
• MODEL

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of alpha-synuclein aggregates called Lewy bodies. Here, nanodecoys were designed from a rabies virus polypeptide with a 29 amino acid (RVG29)-modified red blood cell membrane (RBCm) to encapsulate curcumin nanocrystals (Cur-NCs), which could effectively protect dopaminergic neurons. The RVG29-RBCm/Cur-NCs nanodecoys effectively escaped from retic-uloendothelial system (RES) uptake, enabled prolonged blood circulation, and enhanced blood-brain barrier (BBB) crossing after systemic administration. Cur-NCs loaded inside the nanodecoys exhibited the recovery of dopamine levels, inhibition of alpha-synuclein aggregation, and reversal of mitochondrial dysfunction in PD mice. These findings indicate the promising potential of biomimetic nanodecoys in treating PD and other neurodegenerative diseases.

• 单位
  广州中医药大学; 南方医科大学; y; 上海交通大学