Tetraphenylethylene sulfonate derivative as turn-on fluorescent sensor for berberine chloride detection in aqueous solution

作者：Huang, Han-Jun; Gao, Si-Yu; Zhao, Ai-Juan; Ngeontae, Wittaya; Wu, Han-Chun; Wang, Fu-Min^*; Ren, Xiang-Kui^*

来源：Journal of Pharmaceutical and Biomedical Analysis, 2022, 220: 115030.

DOI：10.1016/j.jpba.2022.115030

• Aggregation -induced emission
• Fluorescence sensor
• Berberine chloride
• Turn -on
• Tetraphenylethylene

A negatively-charged tetraphenylethylene derivative (TPE-SE) was designed and synthesized as turn-on fluorescent sensor for berberine chloride (BBC) detection in aqueous solution. The fluorescent property and detection mechanism were elucidated by UV-vis absorption spectra, photoluminescence spectra, dynamic light scattering experiments. The results reveal that the BBC can lead to aggregation-induced emission of TPE-SE due to the electrostatic interactions, endowing TPE-SE with excellent turn-on detecting ability, high selectivity and sensitivity to BBC. The detection limit is as low as 6.58 x 10(-6)M. These results should be applicable to fabricate special turn-on fluorescent sensors towards various antibiotics, and it is crucially important for achieving reasonable control and intake of small biomolecules.

• 单位
  北京理工大学; 天津大学; xk