J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China

作者：He, Panpan; Li, Huan; Liu, Mengyi; Zhang, Zhuxian; Zhang, Yuanyuan; Zhou, Chun; Ye, Ziliang; Wu, Qimeng; Liang, Min; Jiang, Jianping; Wang, Guobao; Nie, Jing; Hou, Fan Fan; Liu, Chengzhang; Qin, Xianhui

来源：Frontiers of Medicine, 2023, 17(1): 156-164.

DOI：10.1007/s11684-022-0932-3

• dietary zinc intake
• new-onset hypertension
• general population
• CHNS

We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults. A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included. Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory. Participants with systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg or diagnosed by a physician or under antihypertensive treatment during the followup were defined as having new-onset hypertension. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary zinc intake and new onset hypertension followed a J-shape (P for non-linearity < 0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake (per mg/day: hazard ratio (HR) 0.93; 95% confidence interval (CI) 0.88-0.98) in participants with zinc intake < 10.9 mg/day, and increased with the increment of zinc intake (per mg/day: HR 1.14; 95% CI 1.11-1.16) in participants with zinc intake >= 10.9 mg/day. In conclusion, there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults, with an inflection point at about 10.9 mg/day.

• 单位
  南方医科大学; 安徽医科大学