From SARS to COVID-19: What we have learned about children infected with COVID-19.

作者：Zhou, Meng-Yao; Xie, Xiao-Li^*; Peng, Yong-Gang; Wu, Meng-Jun; Deng, Xiao-Zhi; Wu, Ying; Xiong, Li-Jing; Shang, Li-Hong

来源：INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 96: 710-714.

DOI：10.1016/j.ijid.2020.04.090

• 2019-nCoV
• COVID-19
• Children
• Coronavirus
• SARS
• SARS-CoV-2

INTRODUCTION: Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain biological, epidemiological and pathological similarities. To date, research has shown that their genes exhibit 79% of identical sequences and the receptor-binding domain structure is also very similar. There has been extensive research performed on SARS; however, the understanding of the pathophysiological impact of coronavirus disease 2019 (COVID-19) is still limited. METHODS: This review drew upon the lessons learnt from SARS, in terms of epidemiology, clinical characteristics and pathogenesis, to further understand the features of COVID-19. RESULTS: By comparing these two diseases, it found that COVID-19 has quicker and wider transmission, obvious family agglomeration, and higher morbidity and mortality. Newborns, asymptomatic children and normal chest imaging cases emerged in COVID-19 literature. Children starting with gastrointestinal symptoms may progress to severe conditions and newborns whose mothers are infected with COVID-19 could have severe complications. The laboratory test data showed that the percentage of neutrophils and the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19 cases. CONCLUSION: Based on these early observations, as pediatricians, this review put forward some thoughts on children's COVID-19 and gave some recommendations to contain the disease.

• 单位
  University of Florida College of Medicine; University of florida college of medicine