Comparison of a series of donor-acceptor-donor type croconium dyes on pH response, near-infrared fluorescence/photoacoustic imaging and photothermal properties

作者：Ouyang, Cheng-Ren; You, Pei-Dan; Lu, Fei; Mei, Hua; Yu, Jie-Lin; Zhu, Zhibo^*; Zhou, Chun-Qiong^*

来源：Dyes and Pigments, 2024, 221: 111780.

DOI：10.1016/j.dyepig.2023.111780

• Cancer theranostic reagents
• D -A -D type croconium dyes
• pH response
• NIR/PA imaging
• Photothermal efficacy

Eight donor-acceptor-donor type croconium dyes with different donor moieties, such as indole, N-methylindole, benzo[e]indole, N-methylbenzo[c,d]indole, benzothiazole and quinoline groups, have been designed and dis-cussed their pH response, near-infrared fluorescence/photoacoustic (NIR/PA) imaging and photothermal prop-erties in solutions and tumor cells. Croconium dye with bisbenzothiazole CBT exhibited the best NIR-imaging. Croconium dye with bisindole CBI-1 showed the best PA-imaging. Dye CBI-3 with bisbenzo[e]indole showed the best photothermal. Four dyes with either indole or benzo[e]indole group CBI-1, CBI-3, CIT and CIQ showed pH response on fluorescence and photoacoustic spectra and photothermal. This study proves that preserving the indole group in croconium dyes was beneficial for their pH response and NIR/PA imaging, and the introduction of quinoline and thiazole groups was detrimental to the photostability. Gathered with pH response, NIR/PA imaging and photothermal property, dye CBI-1 is suitable for structural modification in the future for developing better cancer theranostic reagents.

• 单位
  南方医科大学