Tigliane Diterpenoids with Larvicidal, Antifungal, and α-Glucosidase Inhibitory Activities from Croton damayeshu

作者：Jiang, Zhi-Yong^*; Feng, Jin-E; Duan, Li-Kun; Liu, Chun-Jiang; Li, Xiao-Fei; Huang, Chun-Qiu; Shi, Sheng-Li; Wang, Rui-Rui^*; Zuo, Ai-Xue^*; He, Hong-Ping^*

来源：Journal of Natural Products, 2022, 85(2): 405-414.

DOI：10.1021/acs.jnatprod.1c00977

• CYTOTOXIC PHORBOL ESTERS
• SEEDS
• AMIDES

Thirty-five tigliane diterpenoids and two ent- kaurane diterpenoids were isolated from the leaves of Croton damayeshu, and, among them, compounds 1-10 were characterized as new tigliane diterpenoids. The structures of compounds 1-10 were determined by analysis of their HRESIMS, NMR, and ECD data and by chemical methods. The isolates were assayed for their larvicidal, antifungal, and alpha-glucosidase inhibitory activities, and compounds 8-10 were found to possess larvicidal activities against Plutella xylostella with LC50 values of 0.19, 0.16, and 0.26 mu M, respectively, comparable to the LC50 of 0.14 mu M for the positive control, flubendiamide.

• 单位
  云南大学