Eremophilane sesquiterpenoids from the whole plant of Parasenecio albus with immunosuppressive activity

作者：Zhou, Ming; Duan, Fangfang; Gao, Ying; Peng, Xiaogang; Meng, Xianggao; Ruan, Hanli^*

来源：Bioorganic Chemistry, 2021, 115: 105247.

DOI：10.1016/j.bioorg.2021.105247

• Parasenecio albus
• Eremophilane
• Sesquiterpenoids
• Immunosuppressive activity

Fifteen new highly oxygenated eremophilane sesquiterpenoids, parasubolides A-O (1-15), were obtained from the whole plant of Parasenecio albus. The structures of 1-15 were elucidated based on the interpretation of NMR and HRESIMS data, along with experimental electronic circular dichroism (ECD) and single-crystal X-ray diffraction analysis. Compounds 1-6, and 9-14 represent the first class of 1,2,10-trioxygenated eremophilane lactones. Selected isolates were evaluated for their immunosuppressive activities. Compounds 4, 5, and 12 exhibited moderate inhibition against LPS-induced B-cell proliferation with IC50 values of 23.1, 33.8, and 26.6 mu M, respectively.

• 单位
  中国科学院; 华中科技大学