Carrier-free nanomedicine for enhanced photodynamic tumor therapy through glutathione S-transferase inhibition

作者：Li, Xinyu; Kong, Renjiang; Li, Yanmei; Huang, Jiaqi; Zhou, Xiang; Li, Shiying; Cheng, Hong^*

来源：Chemical Communications, 2022, 58(24): 3917-3920.

DOI：10.1039/d2cc00235c

Antioxidant-defense systems of tumor cells protect them from oxidative damage. Herein, a carrier-free nanomedicine is developed based on chlorine e6 (Ce6) and coniferyl ferulate (Con), which inhibits glutathione S-transferase (GST) activity to hamper antioxidant systems and amplify intracellular oxidative stress for enhanced photodynamic therapy.

• 单位
  广州医学院; 南方医科大学