Cobalt-Catalyzed Hydrolysis/C-H Thiolation Cascade Reaction of N-Aryl Thiocarbamoyl Fluorides with Water: Access to 3-Alkyl-2(3H)-Benzothiazolones

摘要

A cobalt-catalyzed cascade reaction of N-aryl thiocarbamoyl fluorides and water has been developed, providing access to 3-alkyl-2(3H)-benzothiazolones in 48-83% yields. This protocol for 3-alkyl-2(3H)-benzothiazolones precludes bad-smell and toxic reagents. Mechanistic studies suggest that the transformation proceeds through hydrolysis followed by dehydrogenative coupling to form C-S bond involving a radical process.

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