Norbisabolane-type sesquiterpenoid derivatives, benzofuran lignans and a phenolic glycoside from the roots of Glochidion wilsonii Hutch

作者：Gao, Ruixi; Xu, Xuan; Sun, Hao; Cao, Zhijian; Chen, Rui; Zeng, Xiaomei; Chen, Faju; Liao, Maochuan; Li, Jun^*; Liu, Jing Yu^*

来源：Phytochemistry, 2022, 204: 113447.

DOI：10.1016/j.phytochem.2022.113447

• Glochidion wilsonii Hutch
• Euphorbiaceae
• Norbisabolane-type sesquiterpenoid glycoside
• Benzofuran lignan
• Phenolic glycoside
• Structure elucidation
• Chemotaxonomic significance

Three highly oxygenated norbisabolane sesquiterpenoid glycosides (glochiwilsonosides A-C), five benzofuran lignans (glochiwilsonises A-E) and a phenolic glycoside (glochiwilsophe-noside), together with forty-one known compounds, were isolated from the roots of Glochidion wilsonii Hutch. The chemical structures of the compounds were identified by spectroscopic methods and previous literature data. Glochiwilsonoside A displayed anti -proliferative activity on A-549 and RAW 264.7 cell lines with an IC50 value of 34.5 +/- 0.9 mu M and CC50 value of 16.0 +/- 0.9 mu M, respectively. Twenty-three known compounds were reported from the genus Glochidion for the first time, and the chemotaxonomic characteristics of the isolated compounds were also summarized. The bisabolane/norbisabolane-type sesqui-terpenoid derivatives could be used as chemotaxonomic markers for G. wilsonii.

• 单位
  中国科学院; 华中科技大学