Cobalt-Tertiary-Amine-Mediated Hydroxytrifluoromethylation of Alkenes with CF3Br and Atmospheric Oxygen

作者：Li, Qankun; Fan, Wu; Peng, Deqian; Meng, Bingyin; Wang, Shaohan; Huang, Rui; Liu, Shihao; Li, Suhua^*

来源：ACS Catalysis, 2020, 10(7): 4012-4018.

DOI：10.1021/acscatal.0c00498

• alkene
• hydroxytrifluoromethylation
• bromotrifluoromethane
• cobalt
• tertiary amine

The mild and efficient hydroxytrifluoromethylation of alkenes with bromotrifluoromethane (CF3Br) and atmospheric oxygen mediated by cobalt-tertiary amine is described. This reaction proceeds with broad substrate scope and good functional group compatibility. Mechanistic studies indicate that the reaction proceeds through a radical pathway, which is enabled by combination of the previously unexplored highly efficient N-isopropyl-N,2-dimethylpropan-2-amine with Co(II) for the single electron reduction of CF3Br to CF3 radical.

• 单位
  中山大学