Heterogeneous Copper-Catalyzed Cascade Three-Component Reaction of Amines, Carbon Disulfide and 2-Iodoanilines Leading to 2-Aminobenzothiazoles

作者：Zhao Hong; He Wen; Yao Ruiya; Cai Mingzhong^*

来源：ADVANCED SYNTHESIS & CATALYSIS, 2014, 356(14-15): 3092-3098.

DOI：10.1002/adsc.201400381

• 2-aminobenzothiazoles
• cascade reactions
• functionalized MCM-41
• heterogeneous catalysis
• immobilized copper catalyst

The heterogeneous cascade three-component reaction of amines, carbon disulfide (CS2) and 2-iodoanilines was achieved in dimethylformamide (DMF) at 110 degrees C in the presence of 10 mol% of 3-(2-aminoethylamino) propyl-functionalized MCM-41-immobilized copper complex [MCM-41-2N-CuCl] using potassium carbonate (K2CO3) as base, yielding a variety of 2-aminobenzothiazoles in good to excellent yields. This heterogeneous copper catalyst influences the selectivity of the reaction and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decreases in activity.

• 单位
  广东药学院; jiangxi normal univ