A metal-organic cage-based nanoagent for enhanced photodynamic antitumor therapy

作者：Li, Wen-Yan; Zhao, Chao-Wei; Zhang, Yue-Feng; Guan, Qun; Wan, Jing-Jing; Ma, Jian-Ping; Li, Yan-An^*; Dong, Yu-Bin^*

来源：Chemical Communications, 2021, 57(64): 7954-7957.

DOI：10.1039/d1cc02629a

Herein, we report, for the first time, a Pd6L8(NO3)(5.4)(ICG)(6.6) (ICG = indocyanine green) cage-based hexagonal nanoplate (3) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered O-1(2) generation, high cellular uptake selective lysosome-targeting ability, and, consequently, excellent antineoplastic activity.