Influences of gallium substitution on the phase stability, mechanical strength and cellular response of β-tricalcium phosphate bioceramics

作者：Qiu, Chao; Lu, Teliang; He, Fupo^*; Feng, Songheng; Fang, Xibo; Zuo, Fei; Jiang, Qiangguo; Deng, Xin; Ye, Jiandong^*

来源：Ceramics International, 2020, 46(10): 16364-16371.

DOI：10.1016/j.ceramint.2020.03.195

• Calcium phosphate
• Element substitution
• Bioceramics
• Phase stability
• Cellular response

beta-tricalcium phosphate (beta-TCP), a well-accepted synthetic bone grafting biomaterial, is confronted with limitations of poor phase stability and lacking the capacity to mediate the biological functions. In the current study, gallium (Ga) was substituted for calcium in the beta-TCP, and the influences of Ga substitution on the phase stability, compressive strength and cellular response of beta-TCP bioceramics were investigated. The results indicated that substitution of at least 2.5 mol% Ga for calcium prevented the beta-TCP from transforming into alpha-TCP at 1250 degrees C. The beta-TCP bioceramics substituted with 2.5 mol% Ga attained the highest compressive strength. The beta-TCP bioceramics substituted with 2.5 and 5 mol% Ga showed good cytocompatibility, and suppressed in vitro osteoclastic activity as well as osteoblastic differentiation. Considering the favorable mechanical strength and the inhibitory effect on the osteoclastic activity, the beta-TCP bioceramics substituted with 2.5 mol% Ga are promising for treating the bone defect in the pathological state of excessively rapid bone resorption.

• 单位
  广东工业大学