Highly oxygenated ent-atisane and podocarpane diterpenoids from Excoecaria agallocha

作者：Liu, Guangyan; Zhang, Zhisen; Wang, Yuanhao^*; Li, Xuewen^*

来源：NATURAL PRODUCT RESEARCH, 2022, 36(15): 3924-3930.

DOI：10.1080/14786419.2021.1900177

• Excoecaria agallocha
• ent-atisane diterpenoid
• podocarpane diterpenoid
• cytotoxicity

A new highly oxygenated ent-atisane diterpenoid, namely excagallonoid A (1), together with five known analogues (2 - 6) were isolated from the leaves and twigs of Excoecaria agallocha. Their structures were elucidated on the basis of extensive spectroscopic analyses (HRESIMS, UV, IR, 1 D and 2 D NMR), and the absolute configurations of 1 and 5 were determined by single-crystal X-ray diffraction. Compound 1 represents the first example of an ent-atisane diterpenoid featuring a vicinal 2,3-diol moiety. Compounds 1 and 4 exhibited weak cytotoxicities in vitro against RKO colon cancer cells with IC50 values of 28.7 +/- 1.98 and 32.6 +/- 2.81 mu M, respectively.

• 单位
  桂林理工大学; 广州中医药大学; 广东省人民医院