科研之友
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摘要
The research progress of O-H insertion reaction of diazo esters catalyzed by homogeneous transition metal, nonmetal and heterogeneous catalysts in the past 10 years is reviewed. The structures and catalytic systems of various catalysts and their applications in drug development and organic synthesis are described. The substrate diazo ester is easy to prepare, the catalyst is cheap and easy to obtain, and the carbenoid intermediate formed in the reaction process has high reactivity. Therefore, the O-H insertion reaction can occur under mild conditions with efficient construction of C-O bond in considerable yield and enantioselectivity, which is conducive to the development and synthesis of chiral drugs. Finally, transition-metal-catalyzed O-H insertion and green synthesis are prospected.
