Asymmetric Organocatalytic Enantioselective [1+4]-Annulation of Morita-Baylis-Hillman Carbonates with Thiazolyl Enones for Assembling of Dihydrofurans Featuring Thiazole Skeleton

摘要

The phosphine catalyzed enantioselective [1+4]-annulation of 1-aryl-3-(thiazol-5-yl)prop-2-enone with Morita-Baylis-Hillman carbonate was developed, which enabled the formation of structurally diversified 2, 3-dihydrofurans featuring thiazole skeleton in yields of 49%-96% with e. e. of 92%-99% and d. r. from 6: 1 to more than 20: 1. Notably, this work extended the application range of the established catalytic system and provided an excess to the chiral complex heterocyclic compounds containing dihydrofuran and thiazole structural units.

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