Galacto-Oligosaccharide Alleviates Alcohol-Induced Liver Injury by Inhibiting Oxidative Stress and Inflammation

作者：Zhou, Shipeng; Tan, Qiuhua; Wen, Bingjian; Bai, Yan; Che, Qishi; Cao, Hua; Guo, Jiao^*; Su, Zhengquan^*

来源：Metabolites, 2022, 12(9): 867.

DOI：10.3390/metabo12090867

• alcoholic liver disease (ALD)
• antioxidant
• anti-inflammatory
• galacto-oligosaccharide
• hepatoprotective

Alcoholic liver disease (ALD) is a primary cause of mortality and morbidity worldwide. Oxidative stress and inflammation are important pathogenic factors contributing to ALD. We investigated the protective mechanism of galacto-oligosaccharide (GOS) against ALD through their antioxidant and anti-inflammatory activities by performing in vivo and in vitro experiments. Western blot and RT-PCR results indicated that the expression of cytochrome P450 protein 2E1 (CYP2E1) in liver tissues and L02 cells was reduced in the GOS-treated mice compared with the model group. In addition, GOS prominently reduced the expression of Kelch-like ECH-associated protein 1 (Keap1), increased the expression of the nuclear factor erythroid-2-related factor 2 (Nrf2) and haem oxygenase-1 (HO-1) proteins, and enhanced the antioxidant capacity. In addition, GOS decreased inflammation by reducing inflammatory factor levels and inhibiting the mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-kappa B) pathway. Based on these results, GOS may be a prospective functional food for the prevention and treatment of ALD.

• 单位
  广东药学院