Construction of Tetrazole Derivatives via Sequential Ugi-N3/Pd-Catalyzed Isocyanide Insertion Reactions

摘要

Herein, a straightforward method for the construction of tetrazole derivatives has been achieved through Pd-catalyzed isocyanide insertion reactions, which is a good extension for the response of multi-molecule isocyanides. The Ugi-N-3 reaction was introduced to the transformation to enrich the diversity of skeleton structures. The commercially available starting materials and moderate to good yields make this method a valuable tool for generating N-containing heterocyclic compounds.

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