Novel porphyrin-daunomycin hybrids: Synthesis and preferential binding to G-quadruplexes over i-motif

Authors：Zhao P^*; Jin S F; Lu J Z; Lv J L; Wu G Q; Chen P P; Tan C L; Chen D W

Source：Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy , 2014, 137: 227-235.

DOI：10.1016/j.saa.2014.08.123

• Porphyrin-daunomycin hybrids G-quadruplexes i-Motif

Encouraged by the enormous importance attributed to the structure and function of human telomeric DNA, herein we focused our attention on the interaction of a serious of newly prepared porphyrin-daunomycin (Por-DNR) hybrids with the guanine-rich single-strand oligomer (G4) and the complementary cytosine-rich strand (i-motif). Various spectral methods such as absorption and fluorescence titration, surface-enhanced Raman and circular dichroism spectrum were integrated in the experiment and it was found that these Por-DNR hybrids could serve as prominent molecules to recognize G4 and i-motif. What is more, interesting results were obtained that the hybrids with longer flexible links are more favorable in binding with both G4 and i-motif than the hybrid with shorter linkage. These Por-DNR hybrids may help to develop new ideas in the research of human telomeric DNA with small molecules.