Ugi Four-Component Reaction Based on in-situ Capture of Isocyanide and Post-Modification Tandem Reaction: One-Pot Synthesis of Nitrogen Heterocycles

作者：Luo, Xianghao; Xie, Yibi; Huang, Nianyu; Wang, Long^*

来源：CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 42(3): 838-846.

DOI：10.6023/cjoc202108030

• in-situ capture of isocyanide
• Ugi four-component reaction
• post-modification tandem reaction
• green isocyanide chemistry
• one-pot synthesis

A novel strategy of Ugi four-component and post-modification tandem reaction based on in-situ capture of isocyanide is reported in this paper. According to this reaction strategy, the isocyanide was prepared in situ and immediately captured to participate in Ugi four-component reaction and the subsequent modification tandem reaction. Compared with the previous reports, based on in-situ capture of isocyanide was realized in the Ugi four-component reaction and post-modification tandem reaction, which solved the problems of isocyanide instability, high toxicity and unfriendly to the environment in the reaction. Mild reaction system conditions and simplified preparation method provide a novel green and pollution-free strategy for the tandem reaction of Ugi four-component and post modification series reaction with isocyanide.