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摘要
A novel Lewis- and Bronsted-acid mediated electrophilic addition cyclization/amidation reaction of 1,6-enynes with nitriles to synthesize 3-enamide-substituted dihydrobenzofurans has been developed. The transformation involves the addition of a Bronsted acid as the electrophilic reagent to enynes, followed by intramolecular cyclization to form cationic intermediates, and the termination of the reaction by a nitrile as a nucleophile. The main features of the reaction include high atom economy and chemoselectivity, as well as the construction of C-C/C-N bonds in one step.
