Alternative Polyurethane/Gutta-Percha/ZnO Biocomposite for Root Canal Therapy Based on an Efficient Melt Extrusion Additive Manufacturing Strategy

摘要

Thiswork aims to investigate dental root filling custom gutta-percha(GP) properties based on melt extrusion 3D printing for periapicalperiodontal disease treatment. Zinc oxide nanoparticles are incorporatedinto polyurethane/gutta-percha (PGB) composites. A polyurethane/gutta-percha/ZnO(PGB-Zn) biocomposite including BaSO4, polyurethane (PU),GP, and ZnO nanoparticles is designed and fabricated. To improve thedispersion of ZnO nanoparticles, rosin is chosen to modify the surfaceof the ZnO nanoparticles. The PGB-Zn biocomposite exhibits a maximumtensile strength of 26.795 +/- 1.173 MPa and a flexural strengthof 6.037 +/- 0.37 MPa. The chemical interaction between the nanoparticlesand the matrix is found in the physical and mechanical characterizationof the polyurethane/gutta-percha/ZnO (PGB-Zn) biocomposite. The inhibitionzone test and absorbance photometry show that the composite materialinhibits and kills Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The CCK-8 experimental results show thatthe PGB-Zn biocomposite has a cytotoxicity level of 0-I. The obtained PGB-Zn biocomposite in this work can be used for accurateroot canal therapy as a filling biocomposite by a fused extrusionmethod, which effectively decreases the potential risk of the clinicalimplementation of periapical periodontal disease treatment.

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