Regioselective Access to 2-Iminoimidazolidines via AgF-Mediated Cascade Reactions

作者：He, Yiting; Wu, Haiting; Liang, Yunshi; Deng, Huiying; Xiang, Lingling; Gu, Jiangyong; Zhang, Jing^*

来源：Journal of Organic Chemistry, 2022, 87(11): 7480-7486.

DOI：10.1021/acs.joc.2c00219

• CYCLIC GUANIDINES
• DERIVATIVES
• CYCLIZATION
• ANTAGONISTS
• SILVER

A convergent access to substituted 2-iminoimida-zolidines from aromatic amines andN-propargylS-methylthioureais developed via Ag(I)-mediated cascade guanylation-cyclizationreactions. This method features high regioselectivity, excellentefficiency, and mild reaction conditions. Subsequent deprotectionof the Boc (tert-butyloxycarbonyl) group under acidic conditionsprovides expedient access to aryl 2-aminoimidazole derivatives in aconvenient manner.

• 单位
  1; 广州中医药大学