A rare tetrahydroimidazopyridine from the marine-derived fungus Paraconiothyrium sp. YK-03

作者：Gao, Wen-Ke; Song, Xiao-Yan; Li, Shi-Wei; Xue, Bian-Xia; Wu, Hong-Hua; Zhang, Li-Hua^*; Pei, Yue-Hu^*

来源：NATURAL PRODUCT RESEARCH, 2023.

DOI：10.1080/14786419.2023.2262720

• Tetrahydroimidazopyridine
• Paraconiothyrium sp
• chemical structure

A new tetrahydroimidazopyridine named butyl (5R,6R,7S,8S)-5,6,7,8-tetrahydro-6,7,8-trihydroxy-5-(hydroxymethyl)imidazo[1,2-a]pyridine-2-carboxylate(1), together with eight known compounds (2-9), were isolated from the fermentation broth of a marine-derived fungus Paraconiothyrium sp. YK-03. Their chemical structures were elucidated by extensive analysis of one-dimensional and two-dimensional NMR spectroscopy, HR-ESIMS and optical rotation. Among these compounds, compound 1 represented a rare tetrahydroimidazopyridine, and compounds 2-7 were isolated from the Paraconiothyrium species for the first time. A plausible biosynthetic pathway for compound 1 was proposed.

• 单位
  哈尔滨医科大学