Treatment Activity on Metastatic Bone Tumor by Methotrexate-Loaded Co(II) Metal-Organic Frameworks Encapsulated in Hydrogels

作者：Liu, Sihan; Zhang, Lei^*

来源：Science of Advanced Materials, 2023, 15(2): 280-284.

DOI：10.1166/sam.2023.4415

• Coordination Polymer
• Methotrexate
• Hyrogels
• Bone Tumors
• IP

In the present study, a new Co(II)-based coordination polymer with the chemical formula of [Co(H3L)(bpe)0.5] & BULL; H2O] (1; H3L = 4-(2',3'-dicarboxylphenoxy) benzoic acid, bpe = 1,2-bis(4-pyridyl) ethylene) was pre-pared and successfully loaded with methotrexate using the mixed-ligand synthesis approach. Hyaluronic acid/carboxymethyl chitosan hydrogels loaded with Co(II) metal-organic frameworks were prepared by chem-ical synthesis to further control the release of methotrexate. Scanning electron microscopy showed that the hydrogels had a continuous porous structure with pore sizes concentrated in 206-357 & mu;m. Results of real-time polymerase chain reaction indicated that the hydrogels could remarkably reduce the abnormally increased levyels of Flt-1 and Flk-1 in bone tumor peripheral blood vessels. Besides, IGF content was reduced obviously under the treatment of the new hydrogels in a dose and time-dependent manner. Therefore, the hydrogels loaded with Co(II) metal-organic frameworks are expected to be applied in the clinical treatment of bone tumors.

• 单位
  1; 哈尔滨医科大学