Anti-Inflammatory Terpenoids from the Rhizomes of Shell Ginger

作者：Xiong, Tao; Zeng, Jia; Chen, Lu; Wang, Lutong; Gao, Jianxin; Huang, Lanxuan; Xu, Jingwen; Wang, Yihai^*; He, Xiangjiu^*

来源：Journal of Agricultural and Food Chemistry, 2023, 72(1): 424-436.

DOI：10.1021/acs.jafc.3c07967

• shell ginger
• Alpinia zerumbet
• terpenoids
• anti-inflammatory
• nitric oxide

Shell ginger (Alpinia zerumbet) is a perennial ornamental plant of ginger native to East Asia, which can be used as a flavoring agent in food or beverage, as well as a traditional Chinese medicine. In this study, a total of 37 terpenoids, including 7 new compounds, zerumin D1 to zerumin D7 (2, 3, 28-30, 36, and 37), and 5 new naturally occurring compounds, zerumin D10 to zerumin D14 (9, 12, 15, 20, and 24), were isolated and identified from the rhizomes of shell ginger. Compound 3 was an unprecedented variant labdane diterpenoid featuring a unique 6/7/6/3 tetracyclic cyclic ether system in its side chain. The anti-inflammatory activities of the isolated terpenoids were assessed in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS). Compound 4 significantly inhibited the production of nitric oxide with an IC50 value of 5.4 mu M. Further investigation revealed that compounds 2 and 3 may inhibit the nuclear translocation of NF-kappa B, thus suppressing the expression of IL-6, IL-1 beta, iNOS, and COX-2 to exert the anti-inflammatory effects.

• 单位
  广东药学院