Ultrafast Response in Nonenzymatic Electrochemical Glucose Sensing with Ni(II)-MOFs by Dimensional Manipulation

作者：Wang, Le; Guo, Gui-Zhi; Wang, Meidi^*; Ruan, Heng-Yu; Wu, Ya-Pan; Wu, Xue-Qian; Zhang, Qi-Chun; Li, Dong-Sheng^*

来源：Inorganic Chemistry, 2023, 62(40): 16426-16434.

DOI：10.1021/acs.inorgchem.3c02107

• METAL-ORGANIC FRAMEWORK
• SENSOR
• NI
• NANOSHEET
• CLUSTERS
• CARBON
• CU

Metal-organic frameworks (MOFs) are emerging as promising candidates for electrochemical glucose sensing owing to their ordered channels, tunable chemistry, and atom-precision metal sites. Herein, the efficient nonenzymatic electrochemical glucose sensing is achieved by taking advantage of Ni(II)-based metal-organic frameworks (Ni(II)-MOFs) and acquiring the ever-reported fastest response time. Three Ni(II)-MOFs ({[Ni6L2(H2O)(26)]4H(2)O}(n) (CTGU-33), {Ni(bib)(1/2)(H2L)(1/2)(H2O)(3)}(n) (CTGU-34), {Ni(phen)(H2L)(1/2)(H2O)(2)}(n) (CTGU-35)) have been synthesized for the first time, which use benzene-1,2,3,4,5,6-hexacarboxylic acid (H6L) as an organic ligand and introduce 1,4-bis(1-imidazoly)benzene (bib) or 1,10-phenanthroline (phen) as spatially auxiliary ligands. Bib and phen convert the coordination mode of CTGU-33, affording structural dimensions from 2D of CTGU-33 to 3D of CTGU-34 or 1D of CTGU-35. By tuning the dimension of the skeleton, CTGU-34 with 3D interconnected channels exhibits an ultrafast response of less than 0.4 s, which is superior to the existing nonenzymatic electrochemical sensors. Additionally, a low detection limit of 0.12 mu M (S/N = 3) and a high sensitivity of 1705 mu A mM(-1) cm(-2) are simultaneously achieved. CTGU-34 further showcases desirable anti-interference and cycling stability, which demonstrates a promising application prospect in the realtime detection of glucose.