Identifying immune checkpoint-related lncRNA biomarkers for immunotherapy response and prognosis in cancers

作者：Gao, Yue; Wang, Xinyue; Dong, Longlong; Qu, Changfan; Lu, Qianyi; Wang, Peng; Xin, Mengyu; Zheng, Wen; Liu, Chenyu; Ning, Shangwei^*

来源：Scientific Data, 2023, 10(1): 663.

DOI：10.1038/s41597-023-02550-z

• LONG NONCODING RNAS
• DENDRITIC CELLS
• POPULATION
• EXPRESSION
• NOMOGRAMS
• EVOLUTION
• BLOCKADE
• SURVIVAL

Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) in tumor-immune. However, precise functions in immunity and potential for predicting ICP inhibitors (ICI) response have been described for only a few lncRNAs. Here, a multiple-step pipeline was developed to identify cancer- and immune-context ICP and lncRNA cooperative regulation pairs (ICPaLncCRPs) across cancers. Immune-related ICPs and lncRNAs were extracted follow immune cell lines and immunologic constant of rejection groups. ICPaLncCRP networks were constructed, which likely to modulate tumor-immune by specific patterns. Common and specific hub ICPaLncs such as MIR155HG, TRG-AS1 and PCED1B-AS1 maybe play central roles in prognosis and circulating. Moreover, these hub ICPaLncs were significantly correlated with immune cell infiltration based on bulk and single-cell RNA sequencing data. Some ICPaLncCRPs such as IDO1-MIR155HG could predict three- and five-year prognosis of melanoma in two independent datasets. We also validated that some ICPaLncCRPs could effectively predict ICI-response follow six independent datasets. Collectively, this study will enhance our understanding of lncRNA functions and accelerate discovery of lncRNA-based biomarkers in ICI treatment.

• 单位
  哈尔滨医科大学