Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer

Authors：Jin, Zheng; Peng, Fei; Zhang, Chao; Tao, Shuang; Xu, Damo^*; Zhu, Zhenhua^*

Source：Heliyon, 2023, 9(2): e13195.

DOI：10.1016/j.heliyon.2023.e13195

• KIF20A
• Cancer
• Expression
• Regulating mechanisms
• Therapeutic target

Kinesin family member 20A (KIF20A) is a member of the kinesin family. It transports chromo-somes during mitosis, plays a key role in cell division. Recently, studies proved that KIF20A was highly expressed in cancer. High expression of KIF20A was correlated with poor overall survival (OS). In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.

• Institution
  广州中医药大学; 广州医学院; 南方医科大学