The valuable role of dynamic 18F FDG PET/CT-derived kinetic parameter Ki in patients with nasopharyngeal carcinoma prior to radiotherapy: A prospective study

作者：Huang, Xiaotao; Zhuang, Mingzan; Yang, Shuai; Wang, Ying; Liu, Qiaodan; Xu, Xiwei; Xiao, Mei; Peng, Yingpeng; Jiang, Ping; Xu, Wenhua; Guo, Shuanshuan; Wang, Rong; Wei, Wei; Zhong, Guihua; Zhou, Yuling; Peng, Shunli; Li, Xuanzi; Cui, Jianqi; Wang, Siyang; Zhang, Yaqin; Liu, Zhigang^*

来源：RADIOTHERAPY AND ONCOLOGY, 2023, 179: 109440.

DOI：10.1016/j.radonc.2022.109440

• Nasopharyngeal carcinoma
• Dynamic PET
• CT
• Patlak analysis
• Ki

Background and Purpose: Dynamic positron emission tomography/computed tomography (PET/CT) served the potential role of characterizing malignant foci. The main objective of this prospective study was to explore the advantage of dynamic PET/CT imaging in characterizing nasopharyngeal carcinoma (NPC).Methods and Materials: Patients with probable head and neck disease underwent a local dynamic PET/CT scan followed by a whole-body static scan. Patlak analysis was used to generate parametric influx rate constant (Ki) images from 48 frames obtained from a dynamic PET/CT scan. By delineating the volumes-of-interest (VOIs) of: primary tumor (PT), lymph node (LN), and normal nasopharyngeal tissues (N), we acquired the corresponding Ki mean and SUVmean of each site respectively to perform the quan-titative statistical analysis.Results: Qualified images of 71 patients with newly diagnosed NPC and 8 without nasopharyngeal malig-nant lesions were finally included. We found the correlations between Ki mean-PT and critical clinical features, including clinical stage (r = 0.368), T category (r = 0.643) and EBV-DNA copy status (r = 0.351), and Ki mean-PT differed within the group. SUVmean-PT showed correlations with clinical stage (r = 0.280) and T category (r = 0.472), but could hardly differ systematically within group of clinical features except T category. Ki mean-LN offered the positive correlations with N category (r = 0.294), M category (r = 0.238) and EBV-DNA copy status (r = 0.446), and differed within the group. In addition, Ki mean represented a sensitivity of 94.4 % and a specificity of 100 %, in distinguishing NPC from the non-NPC, when the cut-off was defined as 0.0106. When the cut-off of SUV being defined as 2.03, the sen-sitivity and specificity were both 100 %.Conclusion: Our research confirmed Ki compared favorably to SUV in characterizing NPC and found that Ki can serve as an effective imaging marker of NPC.CO 2022 Elsevier B.V.

• 单位
  南方医科大学; 5; 中山大学