Modification of Food Allergy on the Associations between Early Life Exposure to Size-Specific Particulate Matter and Childhood Allergic Rhinitis

作者：Wu, Chuansha; Tang, Haoran; Wei, Jing; Chen, Hao; Zhao, Zhuohui; Norback, Dan; Zhang, Xin; Lu, Chan; Yu, Wei; Wang, Tingting; Zheng, Xiaohong; Li, Rui; Zhang, Yunquan^*; Zhang, Ling^*

来源：Environmental Science and Technology, 2024, 58(4): 1813-1822.

DOI：10.1021/acs.est.3c05532

• PM1
• PM2.5
• modification
• food allergy
• allergic rhinitis

Previous studies have reported the association between particulate matter (PM) and childhood allergic rhinitis (AR). However, it is unclear whether food allergy (FA) modifies the PM-AR association. We aimed at evaluating the effect of the modification of FA on PM-AR association in preschool children. We adopted a cross-sectional study and conducted a questionnaire survey among preschool children aged 3-6 years in 7 cities in China from June 2019 to June 2020 to collect information on AR and FA. We used a combination of multilevel logistic regression and restricted cubic spline functions to quantitatively assess whether FA modifies the associations between size-specific PM exposure (1 x 1 km) and the risk of AR. The adjusted odds ratios (ORs) for AR among the children with FA as per a 10 mu g/m(3) increase in early life PM1, PM2.5, and PM10 were significantly higher than the corresponding ORs among the children without FA [e.g., OR: 1.58, 95% CI: (1.32, 1.90) vs 1.29, 95% CI: (1.18, 1.41), per 10 mu g/m(3) increase in PM1]. The interactions between FA and size-specific PM exposure and their effects on AR were statistically significant (all p-int < 0.001). FA, as an important part of the allergic disease progression, may modify the PM-AR association in preschool children.

• 单位
  重庆大学; 复旦大学; 上海大学