(±)-Involucrasins A and B, two pairs of flavanone enantiomers from Shuteria involucrata and their inhibitory effects on the proliferation of various cancer cell lines

Authors：Liu, Lu; Li, Xiao-Hong; Ma, Xiao-Xia; Tan, Wen-Hong; Ma, Wen-Zhe; Shen, Yun-Fu; Khan, Afsar; Zhou, Zhi-Hong; Yang, Zhu-Ya^*

Source：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24(7): 641-647.

DOI：10.1080/10286020.2021.1952187

• Shuteria involucrata
• flavanone enantiomers
• cytotoxic activity
• involucrasin A
• involucrasin B
• natural
• products

(+/-)-Involucrasins A (1) and B (2), two pairs of flavanone enantiomers were isolated from Shuteria involucrata. Structurally, both 1 and 2 are rare representatives of 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis and comparison with the literature data. Involucrasin B (2) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, and HCT116 cell lines with IC50 values ranging from 7.9-22.7 mu M. Involucrasin A (1) exhibited weak inhibitory activity against Caco-2 and MCF-7 cell lines with IC50 values of 25.8 and 26.5 mu M, respectively.

• Institution
  云南大学