Expanded roles for the MutL family of DNA mismatch repair proteins.

作者：Furman, Christopher; Elbashir, Ryan; Alani, Eric

来源：Yeast, 2020.

DOI：10.1002/yea.3512

• MLH proteins
• Mismatch repair
• Saccharomyces cerevisiae
• adaptation
• endonuclease
• meiotic crossing over

The MutL family of DNA mismatch repair proteins playsa critical role in excising andrepairing misincorporation errors during DNA replication. In many eukaryotes, members of thisfamily have evolved tomodulate and resolve recombination intermediatesinto crossovers duringmeiosis. In these organisms, such functionspromote the accurate segregation of chromosomes during the Meiosis I division. What alterations occurred in MutL homolog (MLH) family members that enabled them to acquire these new roles? In this review we present evidence that the yeast Mlh1-Mlh3 and Mlh1-Mlh2 complexes have evolved novel enzymatic and non-enzymatic activities and protein-protein interactions that are critical for their meiotic functions. Curiously, even with these changes, these complexes retain backup and accessory roles in DNA mismatch repair during vegetative growth.

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