Oxidative C-H/N-H Carbonylation of Benzamide by Nickel Catalysis with CO as the Carbonyl Source

作者：Kang, Chen; Xu, Jiawei; Li, Xuan; Wang, Shoucai; Jiang, Guangbin^*; Ji, Fanghua^*

来源：Journal of Organic Chemistry, 2022.

DOI：10.1021/acs.joc.2c00673

• ATMOSPHERIC-PRESSURE
• BOND ACTIVATION
• PHTHALIMIDES
• ACCESS
• AMIDES
• C(SP(2))-H
• RUTHENIUM
• CHLORIDES
• MONOXIDE
• HALIDES

An efficient and direct carbonylation of amino-quinoline benzamides has been developed using abundant and inexpensive Ni(OAc)2.4H(2)O as the catalyst and carbon monoxide as a cost-efficient C1 building block. This process features good functional-group tolerance and can be conducted on gram scale. The directing group can be easily removed under mild conditions.

• 单位
  桂林理工大学