科研之友
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摘要
The copper-catalyzed, highly enantioselective alkyl and aryl/azolation of alkenes is reported. The employment of the chiral carbazole-based bisoxazoline (Cbzbox) ligand is critical to the success of this chemistry. Anionic tridentate ligands improve the reducibility of copper complexes, facilitating alkyl/aryl radical generation and providing good enantiocontrol in the azolation. The three-component coupling reactions feature mild reaction conditions and tolerate broad range of functional groups. This strategy allows straightforward introduction of valuable azole functionalities into a elaborated molecular system through direct C-H functionalization.
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单位中国科学院; 中国科学院研究生院
