Maytansine-loaded star-shaped folate-core PLA-TPGS nanoparticles enhancing anticancer activity

作者：Tang Xiaolong; Dai Hong^*; Zhu Yongxiang; Tian Ye; Zhang Rongbo; Mei Rengbiao; Li Deqiang

来源：American Journal of Translational Research, 2014, 6(5): 528-537.

• Maytansine
• targeted delivery
• chemotherapy
• folate
• nanomedicine

The efficient delivery of therapeutic molecule agents into target cells of interest is a critical challenge to broad application of non-viral vector systems. In this research, maytansine-loaded star-shaped folate-core polylactide-D-alpha-tocopheryl polyethylene glycol 1000 succinate (FA-PLA-TPGS) block copolymer was applied to be a vector of maytansine for folate receptor positive (FR+) breast cancer therapy. The uptake of maytansine nanoparticles by SKBR3 cells were observed by fluorescence microscopy and confocal laser scanning microscopy. The cell viability of maytansine-NPs in SKBR3 cells was assessed according to the changed level of intracellular microtubules and apoptosis-associated proteins. The cytotoxicity of the SKBR3 cells was significantly increased by maytansine-NPs when compared with control groups. In conclusion, the maytansine-NPs offer a considerable potential formulation for FR-expressing tumor targeting biotherapy.

• 单位
  浙江大学; 武汉大学; 安徽大学