Access to azonanes via Pd-catalyzed decarboxylative [5+4] cycloaddition with exclusive regioselectivity

作者：Liu, Yin; He, Yicheng; Liu, Yang; Wei, Kun; Guo, Wusheng^*

来源：Organic Chemistry Frontiers, 2021, 8(24): 7004-7008.

DOI：10.1039/d1qo01405f

• 1,3-DIPOLAR 3+6 CYCLOADDITION
• AZOMETHINE YLIDES
• CONSTRUCTION
• HETEROCYCLES
• EFFICIENT
• TROPONE
• ASPIDOSPERMINE
• CYCLIZATION
• METATHESIS
• ANNULATION

A highly efficient approach for the synthesis of azonanes via Pd-catalyzed decarboxylative [5 + 4] cycloaddition has been developed. This procedure utilizes methylene cyclic carbonates as a C5-dipole and 1-azadiene as a C4-synthon. The reactions could be performed at room temperature. The protocol features wide functional group tolerance with exclusive regioselectivity and generates CO2 as the only byproduct.

• 单位
  西安交通大学