Near-Infrared Photooxygenation Theranostics Used for the Specific Mapping and Modulating of Amyloid-β Aggregation

作者：Yang, Jinrong; Wang, Xin; Liu, Jinsheng; Chi, Weijie; Zhang, Lei; Xiao, Lehui^*; Yan, Jin-wu^*

来源：Analytical Chemistry, 2022, 94(45): 15902-15907.

DOI：10.1021/acs.analchem.2c04042

• IN-VIVO DETECTION
• DISEASE
• PROBES

The photooxygenation of amyloid-fi (Afi) protein is considered a promising strategy against Alzheimer's disease (AD). The inhibition of Afi aggregation or depolymerization of Afi aggregates can effectively alleviate and improve the condition of AD. Herein, we report a series of "off-on" near-infrared quinolinium photosensitizers (QM20-QM22) based on D -K-A structures using a target-sensing catalyst activation (TaSCAc) strategy. They exhibit turn-on fluorescence when bonded to Afi aggregates and generate singlet oxygen to achieve the specific imaging and photooxygenation of Afi aggregates, leading to attenuated Afi aggregates, enhancing their clearance through the microglial lysosomal pathway, decreasing their neurotoxicity. This study will shed light on the development of the photooxygenation of misfolded proteins for the treatment of neurodegenerative diseases.

• 单位
  南开大学; 海南大学