科研之友
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摘要
In the complex tumor microenvironment, TGF beta is a pleiotropic cytokine involved in regulating cellular processes such as cancer cell proliferation, apoptosis and metastasis. TGF beta defines three subtypes (TGF beta 1, TGF beta 2, and TGF beta 3), of which TGF beta is highly expressed in many cancers, especially those showing high dissemination potential. In addition, increased expression of TGF beta in multiple cancers is usually positively correlated with epithelial mesenchymal transition (EMT) and coordinated with the expression of genes driving EMT-related genes. TGF beta signaling in the tumor microenvironment inhibits the antitumor function of multiple immune cell populations, including T cells and natural killer cells, and the resulting immunosuppression severely limits the efficacy of immune checkpoint inhibitors and other immunotherapeutic approaches. As a major pathway to enhance the efficacy of cancer immunotherapy effects, the role of TGF beta signaling inhibitors have been evaluated in many clinical trials. However, the potential functions and mechanisms of TGF beta 1, TGF beta 2 and TGF beta 3 in gastric cancer progression and tumor immunology are unclear. In this study, we comprehensively analyzed TGF beta 1, TGF beta 2 and TGF beta 3 and gastric cancer microenvironmental features, including immune cell infiltration, EMT, hypoxia, mutation, immunotherapy and drug treatment, based on HMUCH sequencing data (GSE184336) and public databases. We also validated the protein expression levels of TGF beta in gastric cancer tissues as well as the role of TGF beta factor in cytology experiments. This report reveals the important role of the TGF beta gene family in gastric cancer and provides possible relationships and potential mechanisms of TGF beta in gastric cancer.
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单位哈尔滨医科大学
