科研之友
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摘要
Tumor Necrosis Factor-alpha (TNF-a) is ubiquitous in the human body and plays a significant role in various physiological and pathological processes. However, TNF-a-induced diseases remain poorly understood with limited efficacy due to the intricate nature of their mechanisms. N6-methyladenosine (m6A) methylation, a prevalent type of epigenetic modification of mRNA, primarily occurs at the post-transcriptional level and is involved in intranuclear and extranuclear mRNA metabolism. Evidence suggests that m6A methylation participates in TNF-a-induced diseases and signaling pathways associated with TNF-a. This review summarizes the involvement of TNF-a and m6A methylation regulators in various diseases, investigates the impact of m6A methylation on TNF-a-induced diseases, and puts forth potential therapeutic targets for treating TNF-a-induced diseases.
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单位哈尔滨医科大学
