MALAT-1 interacts with hnRNP C in cell cycle regulation

作者：Yang Feng; Yi Fan; Han Xiaorui; Du Quan^*; Liang Zicai

来源：FEBS Letters, 2013, 587(19): 3175-3181.

DOI：10.1016/j.febslet.2013.07.048

• MALAT-1
• Long non-coding RNA
• Cell cycle
• hnRNP C

As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that downregulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation.

• 单位
  北京大学