Cyanidin-3-O-β-Glucoside Attenuates Platelet Chemokines and Their in Atherosclerotic Inflammation of Mice

作者：Yao, Yanling; Zhang, Xiandan; Xu, Yixuan; Zhao, Yimin; Song, Fenglin; Tian, Zezhong; Zhao, Mingzhu; Liang, Ying; Ling, Wenhua; Mao, Yu-Heng^*; Yang, Yan^*

来源：Journal of Agricultural and Food Chemistry, 2022.

DOI：10.1021/acs.jafc.2c01844

• cyanidin-3-O
• ? -glucoside
• platelet
• chemokine
• receptor
• atherosclerosis
• in fl ammation

ABSTRACT: Platelet chemokines play well-established roles in the atherosclerotic inflammation. Cyanidin-3-O-??-glucoside (Cy-3g) is one of the main bioactive compounds in anthocyanins, but its effects on chemokines during atherosclerosis have not been determined yet. In the present study, ApoE???/??? mice were fed on the chow diet, high-fat diet (HFD), and HFD-supplemented Cy-3-g at 200, 400, and 800 mg/kg diet. After 16 weeks, Cy-3-g significantly alleviated the atherosclerotic lesion and inhibited platelet aggregation and activation. Moreover, Cy-3-g significantly reduced inflammatory chemokines CXCL4, CXCL7, CCL5, CXCL5, CXCL12, and CCL2 in plasma and downregulated CXCR4, CXCR7, and CCR5 on platelets and peripheral blood mononuclear cells. Besides, Cy-3-g decreased the mRNA of TNF??, IFN??, ICAM-1, VCAM-1, CD68, MMP7, CCL5, CXCR4, and CCR5 in the aorta of mice. Therefore, it suggests that Cy-3-g plays important preventive roles in the process of atherosclerosis via attenuating chemokines and receptors in ApoE???/??? mice.

• 单位
  y; 中山大学; 广东药学院