Regulatory effect of isovitexin on MAPK/NF-κB signal in mice with acute ulcerative colitis

作者：Liu, Ming-Xiu; Li, Ting; Wang, Wei-Guang; Guo, Jing; Wang, Rui-Rui; He, Hong-Ping; Li, Shu-Quan; Li, Yan-Ping^*

来源：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023, 25(8): 765-782.

DOI：10.1080/10286020.2022.2142121

• Isovitexin
• ulcerative colitis
• MAPK/NF-kappa B signaling pathway

The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity (p < 0.01). In addition, isovitexin inhibited the expression of MyD88, TLR4 and NF-kappa B p65 proteins. At the same time, isovitexin can inhibit the activation of MAPK/NF-kappa B signaling pathway in RAW264.7 cells. In conclusion, isovitexin has a protective effect on UC mice, and its improvement mechanism of UC might be related to MAPK/NF-kappa B signaling pathway. @@@ [GRAPHICS]

• 单位
  云南大学